LymphedemaV1, Main, Exploration, bibRecord, 005D30

Effects of antiresorptive agents on osteomyelitis

Identifieur interne : 005D30 ( Main/Exploration ); précédent : 005D29; suivant : 005D31

Effects of antiresorptive agents on osteomyelitis

Auteurs : Dan Li [États-Unis] ; Kirill Gromov [États-Unis, Danemark] ; Steven T. Proulx [États-Unis] ; Chao Xie [États-Unis] ; Jie Li [États-Unis] ; Daniel P. Crane [États-Unis] ; Kjeld S Balle [Danemark] ; Regis J. O Eefe [États-Unis] ; Hani A. Awad [États-Unis] ; Lianping Xing [États-Unis] ; Edward M. Schwarz [États-Unis]

Source :

Annals of the New York Academy of Sciences [ 0077-8923 ] ; 2010-04.

RBID : ISTEX:FB83297763F6B5361301CC328B94AA6C2E2665E7

Abstract

The effects of antiresorptive agents (e.g., alendronate [Aln], osteoprotegerin [OPG]) on bone infection are unknown. Thus, their effects on implant‐associated osteomyelitis (OM) were investigated in mice using PBS (placebo), gentamycin, and etanercept (TNFR:Fc) controls. None of the drugs affected humoral immunity, angiogenesis, or chronic infection. However, the significant (P < 0.05 vs. PBS) inhibition of cortical osteolysis and decreased draining lymph node size in Aln‐ and OPG‐treated mice was associated with a significant (P < 0.05) increase in the incidence of high‐grade infections during the establishment of OM. In contrast, the high‐grade infections in TNFR:Fc‐treated mice were associated with immunosuppression, as evidenced by the absence of granulomas and presence of Gram+ biofilm in the bone marrow. Collectively, these findings indicate that although antiresorptive agents do not exacerbate chronic OM, they can increase the bacterial load during early infection by decreasing lymphatic drainage and preventing the removal of necrotic bone that harbors the bacteria.

Url:

DOI: 10.1111/j.1749-6632.2009.05210.x

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en">The effects of antiresorptive agents (e.g., alendronate [Aln], osteoprotegerin [OPG]) on bone infection are unknown. Thus, their effects on implant‐associated osteomyelitis (OM) were investigated in mice using PBS (placebo), gentamycin, and etanercept (TNFR:Fc) controls. None of the drugs affected humoral immunity, angiogenesis, or chronic infection. However, the significant (P < 0.05 vs. PBS) inhibition of cortical osteolysis and decreased draining lymph node size in Aln‐ and OPG‐treated mice was associated with a significant (P < 0.05) increase in the incidence of high‐grade infections during the establishment of OM. In contrast, the high‐grade infections in TNFR:Fc‐treated mice were associated with immunosuppression, as evidenced by the absence of granulomas and presence of Gram+ biofilm in the bone marrow. Collectively, these findings indicate that although antiresorptive agents do not exacerbate chronic OM, they can increase the bacterial load during early infection by decreasing lymphatic drainage and preventing the removal of necrotic bone that harbors the bacteria.</div>
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Effects of antiresorptive agents on osteomyelitis

Effects of antiresorptive agents on osteomyelitis

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